Improvement of biocompatibility of high molecular weight poly-3-hydroxybutyrate by blending with its functionalized oligomers

Anatoly N. Boyandin; Ljublyana M. Dvoinina; Aleksey G. Sukovatyi; Anna A. Sukhanova; Natalya L. Ertiletskaya

doi:10.15826/chimtech.2024.11.1.01

Improvement of biocompatibility of high molecular weight poly-3-hydroxybutyrate by blending with its functionalized oligomers

Anatoly N. Boyandin, Ljublyana M. Dvoinina, Aleksey G. Sukovatyi, Anna A. Sukhanova, Natalya L. Ertiletskaya

Abstract

Oligomers of poly-3-hydroxybutyrate (PHB) were prepared by aminolysis of high molecular weight PHB with ethylenediamine and 1,4-diaminobutane. Polymer-oligomer blends (10, 30, and 50% content of the oligomers) were prepared as films by solution casting. As the content of oligomers increased, a gradual increase in the hydrophilicity of the polymer surface was observed, resulting reflected in the water contact angle decrease from 84° to 72–76°. In addition, a moderate decrease in elongation at break, Young's modulus, and tensile strength for the blends were observed as more oligomer was added to the film. Finally, the viability of NIH-3T3 mouse fibroblasts was higher compared to intact PHB when growing in non-prepared polymer/oligomer mixtures. These findings confirm the benefits of the introduction of a hydrophilic functionalized oligomer into the PHB matrix in terms of improving the biocompatibility of the resulting polymer/oligomer blends.

Keywords

biocompatible materials; poly-3-hydroxybutyrate; functionalized oligomers; aminolysis; polymer-oligomer blends; biocompatibility

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DOI: https://doi.org/10.15826/chimtech.2024.11.1.01

Copyright (c) 2023 Anatoly N. Boyandin, Ljublyana M. Dvoinina, Aleksey G. Sukovatyi, Anna A. Sukhanova, Natalya L. Ertiletskaya

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