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New opportunities for the synthesis of quinoxaline derivatives

Olga S. Koptyaeva, Yuriy A. Azev, Yuriy M. Shafran, Tatyana A. Pospelova, Oleg N. Chupakhin

Abstract


Convenient methods for the synthesis of quinoxaline derivatives with the use of nucleophilic aromatic substitution of hydrogen in heteroaromatic part of molecule in conditions of the acid catalysis were elaborated. The reactions of substitution of fluorine with amines in aromatic ring of 6,7-difluoroquinoxaline with the formation of monofluoro derivatives were studied.

Keywords


quinoxalines; 6,7-difluoroquinoxalines; quinoxalin-2-ones; 6,7-dufluoroquinoxalin-2-ones; nucleophiles

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References


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DOI: https://doi.org/10.15826/chimtech.2019.6.1.02

Copyright (c) 2019 Olga Koptyaeva, Yuriy Azev, Yuriy Shafran, Tatyana Pospelova, Oleg Chupakhin

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