Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic Acids

Sergei N. Igidov; Dmitriy V. Lipin; Aleksey Yu. Turyshev; Svetlana V. Chashchina; Daria A. Shipilovskikh; Ol’ga V. Zvereva; Ksenia A. Mitusova; Pavel S. Silaichev; Nazim M. Igidov

doi:10.15826/chimtech.2023.10.1.02

Synthesis, intramolecular cyclization and anti-inflammatory activity of substituted 2-(2-(Furan-2-carbonyl)hydrazono)-4-oxobutanoic Acids

Sergei N. Igidov, Dmitriy V. Lipin, Aleksey Yu. Turyshev, Svetlana V. Chashchina, Daria A. Shipilovskikh, Ol’ga V. Zvereva, Ksenia A. Mitusova, Pavel S. Silaichev, Nazim M. Igidov

Abstract

A method was proposed for the synthesis of substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids by the reaction of substituted 2,4-dioxobut-2-enoic acids with furan-2-carbohydrazide. It was found that substituted 2-(2-(furan-2-carbonyl)hydrazono)-4-oxobutanoic acids undergo intramolecular cyclization in the presence of propionic anhydride to form the corresponding N'-(2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides. The anti-inflammatory activity of the obtained compounds was studied. It was found that the obtained compounds have pronounced anti-inflammatory activity.

Keywords

dioxobutanoic acids; 2-hydrazono-4-oxobutanoic acids; 3-hydrazonofuran-2(3H)-ones; anti-inflammatory activity; drugs

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DOI: https://doi.org/10.15826/chimtech.2023.10.1.02

Copyright (c) 2022 Sergei N. Igidov, Dmitriy V. Lipin, Aleksey Yu. Turyshev, Svetlana V. Chashchina, Daria A. Shipilovskikh, Ol’ga V. Zvereva, Ksenia A. Mitusova, Pavel S. Silaichev, Nazim M. Igidov

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