Testing the antigenotoxicity and anticytotoxicity properties of  Prunella Grandiflora  L. extract using the example of  Drosophila Melanogaster

Ngonidzaishe Magombe; Viktoria V. Kostenko; Olga N. Antosyuk; Elizaveta V. Bolotnik

doi:10.15826/chimtech.2022.9.2.S14

Testing the antigenotoxicity and anticytotoxicity properties of Prunella Grandiflora L. extract using the example of Drosophila Melanogaster

Ngonidzaishe Magombe, Viktoria V. Kostenko, Olga N. Antosyuk, Elizaveta V. Bolotnik

Abstract

Using the Drosophila melanogaster model object, the presence of protective properties in 10% of Prunella grandiflora L. (Lamiaceae) extract was determined in relation to the toxic and cytotoxic effects of the antitumor drug etoposide in two concentrations of 800 and 8000 µg/kg of nutrient medium. The grass P. grandiflora was collected in the flowering phase in Sverdlovsk region (N 56°09'22.0'', E 058°32'19.6'') in 2021. No genotoxic manifestations of the extract were found. Comparative characteristics of wing parameters under the influence of etoposide at a dose of 800 and 8000 mg showed significant differences in linear and two-dimensional parameters of the wing.

Keywords

extract; prunella; etoposide; morphometry; antigenotoxic

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DOI: https://doi.org/10.15826/chimtech.2022.9.2.S14

Copyright (c) 2022 Ngonidzaishe Magombe, Viktoria V. Kostenko, Olga N. Antosyuk, Elizaveta V. Bolotnik

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