Graphical Abstract

Molecular Complexation of Hederasaponin C with Cholesterol in Aqueous Isopropyl Alcohol

L. A. Yakovishin, V. I. Grishkovets, E. N. Korzh, I. V. Golovchenko, A. A. Nagirnyak

Abstract


The 1:1 molecular complex of ivy triterpene glycoside hederasaponin C (HedC) with cholesterol (Chol) was obtained in aqueous isopropyl alcohol. The stability constant of (3.3 ± 0.7)∙106 (mol/L)–1 was calculated for the complex. The complexation was studied by UV- and ATR IR-Fourier spectroscopy, and method of isomolar series. The hydrogen bonds and hydrophobic interactions are formed in the molecular complex.

Keywords


triterpene glycosides; hederasaponin C; cholesterol; molecular complex

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References


Hostettmann K, Marston A. Saponins. Cambrige: Cambrige University Press; 1995. 548 р.

Tschesche R, Wulff G. Konstitution und eigenschaften der saponine. Planta Medica. 1964;12(3):272–92. doi:10.1055/s-0028-1100180

Wojciechowski K, Orczyk M, Gutberlet T, Geue T. Complexation of phospholipids and cholesterol by triterpenic saponins in bulk and in monolayers. Biochim Biophys Acta Biomembr. 2016;1858(2):363–73. doi:10.1016/j.bbamem.2015.12.001

Yakovishin LA, Grishkovets VI. Molecular complexes of ivy triterpene glycosides with cholesterol. Khimiya Rastitel'nogo Syr'ya. 2018;4:133-40. doi:10.14258/jcprm.2018043607

Grishkovets VI, Sidorov DYu, Yakovishin LA, Arnautov NN, Shashkov АS, Chirva VYa. Triterpene glycosides of Hedera canariensis I. Structures of glycosides L-A, L-B1, L-B2, L-C, L-D, L-E1, L-G1, L-G2, L-G3, L-G4, L-H1, L-H2, and L-I1 from the leaves of Hedera canariensis. Chem Nat Compd. 1996;32(3):360–5. doi:10.1007/BF01372340

Babko AK. Phiziko-khimicheskii analiz kompleksnykh soedinenii v rastvorakh [Physico-chemical analysis of complex compounds in the solutions]. Kiev: Izd-vo AN USSR; 1955. 328 p. Russian.

Yakovishin LA, Grishkovets V.I. Ivy and licorice triterpene glycosides: promising molecular containers for some drugs and biomolecules. Stud Nat Prod Chem. 2018;55:351–83. doi:10.1016/B978-0-444-64068-0.00011-5




DOI: https://doi.org/10.15826/chimtech.2020.7.4.02

Copyright (c) 2020 L. A. Yakovishin, V. I. Grishkovets, E. N. Korzh, I. V. Golovchenko, A. A. Nagirnyak

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