Synthetic approaches to 2-aryl/hetaryl- and 2-(hetaryl)ylidene derivatives of fluorinated 1,3-benzothiazin-4-ones

Emiliya V. Nosova; Olga A. Batanova; Nataliya N. Mochulskaya; Galina N. Lipunova

doi:10.15826/chimtech.2020.7.3.01

Synthetic approaches to 2-aryl/hetaryl- and 2-(hetaryl)ylidene derivatives of fluorinated 1,3-benzothiazin-4-ones

Emiliya V. Nosova, Olga A. Batanova, Nataliya N. Mochulskaya, Galina N. Lipunova

Abstract

A series of 2-hetaryl- and 2-(hetaryl)ylidene substituted 5-fluoro-8-nitro-1,3-benzothiazin-4-ones was synthesized by interaction of 2,6-difluoro-3-nitrobenzoylisothiocyanate with C-nucleophiles. Cyclocondensation of polyfluorobenzoylchlorides with aryl and hetaryl thioamides represents new approach to 1,3-benzothiazin-4-ones. Some compounds proved to be promising for further development of tuberculostatic agents.

Keywords

1,3-benzothiazin-4-ones; 2-fluorobenzoylchloride; 2-fluorobenzoyl-isothiocyanate; indole; pyrrole; cyanomethylbenzimidazole; benzoylmethylbenzimidazole; thioamide; cyclocondensation; tuberculostatics

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References

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DOI: https://doi.org/10.15826/chimtech.2020.7.3.01

Copyright (c) 2020 Emiliya V. Nosova, Olga A. Batanova, Nataliya N. Mochulskaya, Galina N. Lipunova

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