Technology of the pilot production of the tetrahydroquinoline derivative (3aS*,4R*)-4-cyano-1,2,3,3а,4,5-hexahydro-1Н- pyrrolo[1,2-а]quinoline-4-carbothioamide

A. A. Poluikova; A. Yu. Platonova

doi:10.15826/chimtech.2016.3.3.015

Technology of the pilot production of the tetrahydroquinoline derivative (3aS,4R)-4-cyano-1,2,3,3а,4,5-hexahydro-1Н- pyrrolo[1,2-а]quinoline-4-carbothioamide

A. A. Poluikova, A. Yu. Platonova

Abstract

The regulations of the pilot production of (3aS*,4R*)-4-cyano-1,2,3,3а,4,5-hexahydro-1Н-pyrrolo[1,2-а]quinoline-4-carbothioamide designed in Ltd. U-Synthesis is presented in the present work. Main steps of the production are considered, the material balance of the process, specification of main production steps and applied equipment are given.

Keywords

tert-amino effect; cyclization; ortho-vinyl-N,N-dialkylanilines; Knoevenagel condensation; tetrahydroquinolines; CH-active compound

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References

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DOI: https://doi.org/10.15826/chimtech.2016.3.3.015

Copyright (c) 2016 A. A. Poluikova, A. Yu. Platonova

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