The redox transformations and nucleophilic replacements as possible metabolic reactions of the drug “Triazaverin”. The chemical modeling of the metabolic processes

N. R. Medvedeva; I. S. Sapozhnikova; V. L. Rusinov; E. N. Ulomsky

doi:10.15826/chimtech.2015.2.3.025

The redox transformations and nucleophilic replacements as possible metabolic reactions of the drug “Triazaverin”. The chemical modeling of the metabolic processes

N. R. Medvedeva, I. S. Sapozhnikova, V. L. Rusinov, E. N. Ulomsky

Abstract

As a model of metabolic transformations of antiviral drug “Triazaverin” and its analogues‑2-alkylthio‑6-nitro‑1,2,4-triazolo[5,1-c][1,2,4]triazine‑7-ones 1a-d examined the oxidation of alkylthio groups to the corresponding sulfoxides 2a-d and sulfones 3a-d, as well as the process of nucleophilic substitution sulfonyloxy group of cysteine and cysteamine with the formation of compounds 5 and 6.

Keywords

biological active compounds; heterocycles; triazine; Triazaverin; antiviral drug

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References

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DOI: https://doi.org/10.15826/chimtech.2015.2.3.025

Copyright (c) 2015 N. R. Medvedeva, I. S. Sapozhnikova, V. L. Rusinov, E. N. Ulomsky

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